Dr. Nishanth E. Sunny has been awarded a $1.86 million grant from the National Institute of Diabetes & Digestive & Kidney Diseases, NIH (NIDDK/NIH) for his R01 grant proposal entitled, “Metabolic Origins of Nonalcoholic Steatohepatitis.”
In this project, Dr. Sunny and his collaborators will probe for novel mechanisms through which dysfunctional mitochondrial oxidative metabolism promotes inflammation, oxidative stress and progression of nonalcoholic fatty liver disease (NAFLD). Defects in mitochondrial oxidative metabolism are central to the etiology of NAFLD, a major public health problem affecting over 70% of the obese and type 2 diabetes mellitus patients. The impact of these studies will be towards identifying key strategies to reduce oxidative stress and inflammation during NAFLD, specifically by attenuating dysfunctional mitochondrial oxidative flux. These strategies will provide a better paradigm to treat NAFLD and type 2 diabetes mellitus.
