Kasey Moyes and David Mangelsdorf
The 2018 Shorb Lecture, co-sponsored by ANSC and NFSC, was given on October 23 by Dr. David Mangelsdorf, Professor and Chair of the Department of Pharmacology at the University of Texas Southwestern Medical Center. Dr. Mangelsdorf is an Investigator of the Howard Hughes Medical Institute and holds the Alfred G. Gilman Distinguished Chair in Pharmacology and the Raymond and Ellen Willie Distinguished Chair in Molecular Neuropharmacology. His talk was entitled, “FGF21 and metabolism: Eat, drink, and be merry” and was well attended at the Stamp Student Union. Dr. Kasey Moyes chaired the Shorb Committee.
Dr. Mangelsdorf runs a joint laboratory with his long-time collaborator, Dr. Steven Kliewer. Their research focuses on understanding the molecular and physiologic components of signaling pathways that control carbohydrate and lipid metabolism. Most recently, their work has revealed the existence of two endocrine factors, FGF19 and FGF21, which respectively play distinct roles in enterohepatic control of bile acid physiology and neuroendocrine control of stresses. Their lab has discovered several therapeutic targets that are being developed to treat diverse diseases such as cholestasis, obesity, diabetes, fatty liver disease, and nematode parasitism.
The Shorb Lecture series, honoring Dr. Mary Shorb was made possible by funds
donated in 1970 by Merck & Company.
